Job no: 507483
Work type: Post Doc
Location: Main Campus (Gainesville, FL)
Department:29030101 - MD-BIOCHEMISTRY-GENERAL
The Caglayan lab in the Department of Biochemistry and Molecular Biology is currently accepting applications for a Postdoctoral Associate. The research project will focus on deciphering the role and properties of DNA ligases in the multiple pathways of DNA repair.
The Caglayan lab is interested in the molecular mechanisms of genome integrity and biological importance of DNA ligation failure by the effects of oxidative stress using purified DNA repair proteins, nuclear and mitochondrial cell extracts, mouse embryonic fibroblast cells, and yeast (Saccharomyces cerevisiae) cells. In particular, the Caglayan lab has made contributions to a better understanding of innovative and molecular aspects of substrate channeling of repair intermediates during base excision DNA damage repair under oxidative stress cellular conditions (Caglayan et al. Nat. Struc. Mol. Biol., 2014; Caglayan et al. Nucleic Acids Res., 2015; Caglayan and Wilson, DNA Repair, 2015; Caglayan et al. Nucleic Acids Res., 2017; Caglayan et al. Nat. Comm. 2017).
Duties will include:
- Conducting research to decipher the role and properties of DNA ligases in the multiple pathways of DNA repair.
- Supporting projects through original research, collaboration with other team members.
- Researching, interpreting, and critically evaluating primary literature; collection and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook.
- Preparing and editing manuscripts for publication for dissemination of results as well as applications for grants and patents in consultation with the supervisor.
- Attending an annual meeting to disseminate research findings and progress.
- Supervising and training of graduate students (PhD and Master's level), undergraduates, and student workers.
Negotiable based on qualifications and experience.
- PhD degree in the fields of biochemistry, molecular biology, or a related discipline.
- Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.
A strong experimental background with evidence of experimental skills related to cell biology is mandatory. The candidates must have extensive experience in CRISPR/Cas9 gene editing, cell survival or sensitivity assays after treatment with DNA damage inducing agents and small molecule inhibitors, γ-H2AX assay, flow cytometry and fluorescence-activated cell sorting (FACS). Previous working experience with cell cultures of mouse embryonic fibroblasts and human fibroblasts is preferred.
|Special Instructions to Applicants:
To be considered for this position, please upload a Curriculum Vitae, three (3) letters of recommendations, and a statement of research interest.
Final candidate will be required to provide official transcripts to the hiring department upon hire. A transcript will not be considered “official” if a designation of “Issued to Student” is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approval by National Association of Credential Evaluation Services (NACES), which can be found at http://naces.org/.
Application must be submitted by 11:55 p.m. (ET) of the posting end date.
This requisition has been reposted. Previous applicants are still under consideration and need not apply.
|Health Assessment Required:
Advertised: Eastern Daylight Time
Applications close: Eastern Daylight Time
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